Symbol
Name
ID

Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Anemia	Splenomegaly
Disease(s) Associated with TNFRSF11A
autosomal recessive osteopetrosis 7

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal thymus epithelium morphology

enlarged spleen

spleen hyperplasia

abnormal hematopoietic system morphology/development

abnormal common myeloid progenitor cell morphology

abnormal negative T cell selection

extramedullary hematopoiesis

anemia

decreased bone marrow cell number

increased neutrophil cell number

increased granulocyte number

decreased mature B cell number

decreased plasma cell number

decreased B cell number

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

decreased spleen germinal center size

decreased IgA level

abnormal osteoclast physiology

Availability

Mouse Genotype

Tnfrsf11a^del8/Tnfrsf11a^del8

Tnfrsf11a^tm1.1Sral/Tnfrsf11a^tm1.1Sral

Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr

Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx

Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost

Tnfrsf11a^tm1.1Sral/Tnfrsf11a⁺

Tg(Vil1-cre)997Gum/0
Tnfrsf11a^tm1.1Irw/Tnfrsf11a^tm1.1Irw (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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